George Clooney Has ER Reunion with Julianna Margulies, Anthony Edwards and Noah Wyle at Broadway’s Good Night, and Good Luck

Photographers captured the foursome at the starry event’s afterparty, a swanky black tie affair held at the New York Public Library.

Coincidentally, Marguiles and Edwards were both on the New York City stage this season. Marguiles starred in Broadway’s romantic play Left on Tenth, while Edwards led The Counter Off-Broadway. His wife, Mare Winningham — who joined him at the premiere of Good Night, and Good Luck — was part of the Broadway season too, with a role in the ensemble family drama Cult of Love.

Wyle, meanwhile, is back playing a doctor on TV, leading Max’s celebrated hit, The Pitt.

Clooney stars in Good Night, and Good Luck, a performance that marks both his Broadway debut and his first theater role in almost 40 years. He also wrote the play with Grant Heslov, his co-writer on the film’s original screenplay.

Like the movie, the play recounts the real-life story of CBS news journalist Edward R. Murrow’s legendary exposé on Senator Joseph McCarthy. Though Clooney played producer Fred W. Friendly in the film, on stage, he’s stepped into the shoes of Murrow — the role that earned David Strathairn a 2006 Oscar nomination.

That same year, Clooney earned his Oscar, for his supporting role in Syriana. He was also nominated for Best Director and Best Original Screenplay, both for Good Night, and Good Luck.

ER debuted on NBC in 1994 and ran for 15 seasons, before ending in 2009. The groundbreaking medical drama, created by Michael Crichton, also starred Sherry Stringfield, Eriq La Salle and Noah Wyle.

Fans will remember that Clooney left the show in 1999 at the end of season 5, but returned for cameos in season 6 and for the series finale.

In the years since, he has remained in touch with his former castmates. In fact, back in October, Marguiles told PEOPLE that she had reached out to her former costar to give him “a lot of kudos” for his decision to do Broadway.

“I just emailed him and said, ‘I’m so proud of you. You don’t have to do this,’ ” she recalled. “It’s scary, you know, being on Broadway. And the world we live in now, everyone’s a judge, and you have to block all that out and do your work. And so, I’m really proud of him for picking a hard road. It’s not easy work, and I’m really impressed that he’s doing it.”

The two, Marguiles has said, still sign their personal emails to each other ‘Love, Carol’ or ‘Doug.’ “

ER didn’t just give Clooney lasting friendships. During an appearance on The Late Show with Stephen Colbert in February, the actor said that he still remembers lines of dialogue from the series.

“It’s weird. When I did ER, we’d do 12 pages a day of medical dialogue and you could just come in and whip it out. I was 30 years [old],” Clooney added, before demonstrating his recall of the phrase “supraventricular tachycardia” which he said he’s “never gotten wrong since” doing the drama.

He’s had a more difficult time with the dialogue in Good Night, and Good Luck, telling Colbert that memorizing his lines has been “a nightmare.”

“Now I can’t remember anything,” he said. “Honest to God, literally, these are very famous speeches that Murrow wrote and I start to do them and I just sit there going, ‘Uhhh … I don’t remember.’ “