The double-decker was travelling from Peru’s capital Lima to a region of the Amazon rainforest when it lost control, authorities said.
It left the road and fell down a slope in the district of Palca, Junín region, around 160 miles east of Lima yesterday.
Video of the incident shown on local television appeared to show the vehicle, operated by a company named Expreso Molina Líder Internacional, split in two.
Footage also captured local firefighters and police attempting to rescue survivors.
Authorities are still investigating what happened to cause the crash.
Several fatal bus crashes have happened in Peru in recent years, with a British tourist killed in one incident in October 2023.
Six people died in another crash on January 3 this year, when a bus slid into a river. A further 32 were injured.
